Catalog# Size Unit Price Quantity
TACE-SW-20 20 mg $1,550.00

Alpha-Secretase peptide substrate Human APP605-619, >95% pure

AntigenA fluorescence energy transfer (FRET) peptide substrate for tumor necrosis factor (TNF) -¿¿convertase (TACE) (Km ~ 19 ¿M). Cleavage of this TACE substrate II occurs between the alanine and valine residues. Useful for the screening of TACE inhibitors
FormPurified Peptide
Product TypePeptide
SpCrossreactivityRecommended usage: 50 mM Tricine buffer, pH 7.5, containing 100 mM NaCl, 10 mM CaCl2, and 1 mMZnCl2, 10 ¿M TACE Substrate II, 600 nM TACE; incubate at 27°C with mechanical shaking; reaction can be quenched with 50 mM EDTA (final concentration) ; cleavage monitored by excitation at ~ 320 nm and emission at ~ 395 nm
SpeciesReactivityHuman
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