| SpCrossreactivity | The pore region of HCN1 (HCNP15-P) is very conserved among various HCNs. HCN1: mouse, rat, human, rabbit=100%; HCN2: mouse, rat, human (86%); HCN3: mouse (95%), rat (90%); HCN4: rat, human (95%). The HCNP15-P sequence is also conserved in insect (Helothis virescens, 78%), Drosophila (78%) and Sea urchin (S. purpuratus, 69%) HCNs. Therefore, antibodies to HCNP15-P should react with most HCNs and related sequences. Antibody reactivity in various species is not known. |